Heilbronn ▸ Prague
Prague ▸ Heilbronn ⇄2.5 a dayfastest 6h20☾ 1 overnight busFlixBus🇩🇪 Germany → 🇨🇿 Czechia
Direct buses · no change
HeilbronnNurembergPlzeňPrague· 389 km as the crow flies
- 01:25 → 07:50FlixBus N168 ☾ OvernightHeilbronn central train station → Prague (Central Bus Station Florenc) · via Nuremberg, Plzeň6h254 stopsRuns: Mon, Tue, Sat, Sun (some weeks)The night the clocks change (Sun 25 Oct: 01:25 → 06:50)Book on FlixBus ↗
- 08:55 → 15:25FlixBus N1315Heilbronn central train station → Prague (Central Bus Station Florenc) · via Nuremberg, Plzeň6h302 stops
- 15:30 → 21:50FlixBus N1316Heilbronn central train station → Prague (Central Bus Station Florenc) · via Nuremberg, Beroun6h202 stopsRuns: Mon, Tue, Fri, Sat, SunBook on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Heilbronn to Prague?
Yes. 2.5 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Heilbronn to Prague?
The fastest takes 6h20; the slowest 6h30, for 389 km as the crow flies.
When do the buses leave?
The earliest leaves at 01:25 and the latest at 15:30, local time in Heilbronn. Not every bus runs every day: pick a date above.
Is there a night bus from Heilbronn to Prague?
Yes: 1 overnight departure in the timetable, for example 01:25 arriving 07:50.