pickthebus

Lyon ▸ Rome

Rome ▸ Lyon ⇄
2.5 a dayfastest 14h10☾ 2 overnight busesBlaBlaCar Bus, FlixBus🇫🇷 France → 🇮🇹 Italy

Direct buses · no change

LyonChambéryTurinGenoaBolognaFlorenceRome· 749 km as the crow flies
  • 01:15 → 16:05
    FlixBus N521 ☾ Overnight
    Lyon (Gerland Bus Station) → Rome Tiburtina Bus station · via Turin, Bologna, Florence
    14h504 stops
    Runs: DailyThe night the clocks change (Sun 25 Oct: 01:15 → 15:05)Book on FlixBus ↗
  • 05:35 → 20:15
    BlaBlaCar Bus
    Lyon - Gerland Bus Station → Rome - Tiburtina · via Turin, Bologna, Florence
    14h403 stops
    Runs: Only Mon 26 Octthe open data has only these datesBook on BlaBlaCar Bus ↗
  • 09:35 → 23:45
    FlixBus 516
    Lyon (Gerland Bus Station) → Rome Tiburtina Bus station · via Turin, Genoa, Florence, Siena
    14h104 stops
    Runs: Mon, Tue, Fri, Sat, SunBook on FlixBus ↗
  • 20:45 → 12:15+1
    FlixBus N580 ☾ Overnight
    Lyon (Gerland Bus Station) → Rome Anagnina · via Chambéry, Turin, Genoa, Bologna…
    15h305 stops
    Runs: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sat 24 Oct: 20:45 → 11:15+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026) and BlaBlaCar Bus (file of 18 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. Contains BlaBlaCar Bus timetable data (transport.data.gouv.fr), ODbL 1.0. How we build this.

Quick answers

Is there a direct bus from Lyon to Rome?

Yes. 2.5 a day on average, with BlaBlaCar Bus and FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Lyon to Rome?

The fastest takes 14h10; the slowest 15h30, for 749 km as the crow flies.

When do the buses leave?

The earliest leaves at 01:15 and the latest at 20:45, local time in Lyon. Not every bus runs every day: pick a date above.

Is there a night bus from Lyon to Rome?

Yes: 2 overnight departures in the timetable, for example 01:15 arriving 16:05.