pickthebus
Direct buses › From Lyon

Lyon ▸ Siena

Siena ▸ Lyon ⇄
1.1 a dayfastest 11h20☾ 1 overnight busFlixBus🇫🇷 France → 🇮🇹 Italy

Direct buses · no change

LyonChambéryTurinMilanBolognaFlorenceSiena· 580 km as the crow flies
  • 09:35 → 20:55
    FlixBus 516
    Lyon (Gerland Bus Station) → Siena (Stazione FS) · via Turin, Genoa, Florence
    11h203 stops
    Runs: Mon, Tue, Fri, Sat, SunBook on FlixBus ↗
  • 23:00 → 11:20+1
    FlixBus N527 ☾ Overnight
    Lyon (Gerland Bus Station) → Siena (Stazione FS) · via Chambéry, Turin, Milan, Bologna…
    12h206 stops
    Runs: Thu to Sun (some weeks)The night the clocks change (Sat 24 Oct: 23:00 → 10:20+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Quick answers

Is there a direct bus from Lyon to Siena?

Yes. 1.1 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Lyon to Siena?

The fastest takes 11h20; the slowest 12h20, for 580 km as the crow flies.

When do the buses leave?

The earliest leaves at 09:35 and the latest at 23:00, local time in Lyon. Not every bus runs every day: pick a date above.

Is there a night bus from Lyon to Siena?

Yes: 1 overnight departure in the timetable, for example 23:00 arriving 11:20 the next morning.

More from Lyon

Every bus from Lyon

More to Siena

Every bus from Siena