Florence to Prague bus: 1.9 a day, fastest 15h05

1.9 a dayfastest 15h05☾ 2 overnight busesFlixBus🇮🇹 Italy → 🇨🇿 Czechia

Direct buses · no change

FlorenceBolognaPaduaMestrePortogruaroUdinePrague· 742 km as the crow flies

18:20 → 09:25⁺¹
FlixBus N538 ☾ Overnight
Florence (Villa Costanza) → Prague (Central Bus Station Florenc) · via Bologna, Verona, Trento, Bolzano…
15h057 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 18:20 → 08:25+1)Book on FlixBus ↗
20:25 → 13:45⁺¹
FlixBus N1533 ☾ Overnight
Florence (Villa Costanza) → Prague (Main Railway Station) · via Bologna, Padua, Mestre, Portogruaro…
17h209 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 20:25 → 12:45+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

☾ Overnight: leave 18:20, arrive 09:25

The plane is 11h27 quicker door to door, but the night bus spends your night on the road instead of a day.

Bus · fastest direct15h57

To Florence (Villa Costanza)24 min
At the stop before departure15 min
FlixBus N53815h05
From Prague (Central Bus Station Florenc)13 min

Plane · nonstop FLR to PRG4h30

To Florence (FLR)20 min
Check-in & security1h30
Flight FLR to PRG1h45
Landing to exit20 min
From PRG35 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance.

Train instead?

No direct train from Florence to Prague in pickthetrain's timetables: the bus is the no-change way.

Where Florence goes by direct train ↗

Flying instead?

1 airline fly Florence to Prague nonstop. Book on the airline's own site:

VoloteaFLR→PRGBook direct ↗

Compare on picktheflight ↗

Quick answers

Is there a direct bus from Florence to Prague?

Yes. 1.9 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Florence to Prague?

The fastest takes 15h05; the slowest 17h20, for 742 km as the crow flies.

When do the buses leave?

The earliest leaves at 18:20 and the latest at 20:25, local time in Florence. Not every bus runs every day: pick a date above.

Is there a night bus from Florence to Prague?

Yes: 2 overnight departures in the timetable, for example 18:20 arriving 09:25 the next morning.

Florence ▸ Prague

Direct buses · no change

Quick answers

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