Karlsruhe to Prague bus: 4.5 a day, fastest 8h25

4.5 a dayfastest 8h25☾ 1 overnight busFlixBus🇩🇪 Germany → 🇨🇿 Czechia

Direct buses · no change

KarlsruheStuttgartNurembergZwickauChemnitzDresdenPrague· 450 km as the crow flies

06:25 → 15:25
FlixBus N1315
Karlsruhe central train station → Prague (Central Bus Station Florenc) · via Stuttgart, Heilbronn, Nuremberg, Plzeň
9h008 stops
Runs: DailyThe night the clocks change (Sun 25 Oct: 05:25 → 14:25)Book on FlixBus ↗
08:35 → 17:30
FlixBus 1307
Karlsruhe central train station → Prague (Main Railway Station) · via Stuttgart, Munich
8h553 stops
Runs: DailyBook on FlixBus ↗
12:15 → 22:40
FlixBus 321 / 321A
Karlsruhe central train station → Prague (Central Bus Station Florenc) · via Stuttgart, Nuremberg, Zwickau, Chemnitz…
10h258 stops
Runs: DailyBook on FlixBus ↗
13:20 → 21:50
FlixBus N1316
Karlsruhe central train station → Prague (Central Bus Station Florenc) · via Stuttgart, Heilbronn, Nuremberg, Beroun
8h308 stops
Runs: Mon, Tue, Fri, Sat, SunBook on FlixBus ↗
23:25 → 07:50⁺¹
FlixBus N168 ☾ Overnight
Karlsruhe central train station → Prague (Central Bus Station Florenc) · via Stuttgart, Heilbronn, Nuremberg, Plzeň
8h259 stops
Runs: Mon, Fri, Sat, Sun (some weeks)The night the clocks change (Sat 24 Oct: 23:25 → 06:50+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

The bus is the fastest way door to door

Bus · fastest direct9h07

To Karlsruhe central train station14 min
At the stop before departure15 min
FlixBus N1688h25
From Prague (Central Bus Station Florenc)13 min

Train · fastest direct10h28

To Karlsruhe Hbf1 min
Before departure10 min
EC 45910h16
From Praha hlavní nádraží1 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

6 a weekdirect trains, fastest 10h16

Deutsche Bahn. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Flying instead?

Nothing flies Karlsruhe to Prague nonstop in picktheflight's airline data.

Check flights on picktheflight ↗

Quick answers

Is there a direct bus from Karlsruhe to Prague?

Yes. 4.5 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Karlsruhe to Prague?

The fastest takes 8h25; the slowest 10h25, for 450 km as the crow flies.

When do the buses leave?

The earliest leaves at 06:25 and the latest at 23:25, local time in Karlsruhe. Not every bus runs every day: pick a date above.

Is there a night bus from Karlsruhe to Prague?

Yes: 1 overnight departure in the timetable, for example 23:25 arriving 07:50 the next morning.

Karlsruhe ▸ Prague

Direct buses · no change

Quick answers

More from Karlsruhe

More to Prague