Prague to Karlsruhe bus: 4.5 a day, fastest 8h35

4.5 a dayfastest 8h35☾ 1 overnight busFlixBus🇨🇿 Czechia → 🇩🇪 Germany

Direct buses · no change

PragueDresdenChemnitzZwickauNurembergStuttgartKarlsruhe· 450 km as the crow flies

06:40 → 15:15
FlixBus N1316
Prague (Central Bus Station Florenc) → Karlsruhe central train station · via Beroun, Nuremberg, Heilbronn, Stuttgart
8h358 stops
Runs: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sun 25 Oct: 05:40 → 14:15)Book on FlixBus ↗
10:30 → 21:20
FlixBus 321 / 321A
Prague (Central Bus Station Florenc) → Karlsruhe central train station · via Dresden, Chemnitz, Zwickau, Nuremberg…
10h508 stops
Runs: DailyBook on FlixBus ↗
13:05 → 21:55
FlixBus 1307
Prague (Main Railway Station) → Karlsruhe central train station · via Munich, Stuttgart
8h503 stops
Runs: DailyBook on FlixBus ↗
15:10 → 23:50
FlixBus N1315
Prague (Central Bus Station Florenc) → Karlsruhe central train station · via Plzeň, Nuremberg, Heilbronn, Stuttgart
8h408 stops
Runs: DailyBook on FlixBus ↗
22:00 → 06:35⁺¹
FlixBus N168 ☾ Overnight
Prague (Central Bus Station Florenc) → Karlsruhe central train station · via Plzeň, Nuremberg, Heilbronn, Stuttgart
8h359 stops
Runs: Thu to Sun (some weeks)The night the clocks change (Sat 24 Oct: 22:00 → 05:35+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

The bus is the fastest way door to door

Bus · fastest direct9h17

To Prague (Central Bus Station Florenc)13 min
At the stop before departure15 min
FlixBus N13168h35
From Karlsruhe central train station14 min

Train · fastest direct10h42

To Praha hlavní nádraží1 min
Before departure10 min
EC 45810h30
From Karlsruhe Hbf1 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

1 a daydirect trains, fastest 10h30

České dráhy. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Flying instead?

Nothing flies Prague to Karlsruhe nonstop in picktheflight's airline data.

Check flights on picktheflight ↗

Quick answers

Is there a direct bus from Prague to Karlsruhe?

Yes. 4.5 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Prague to Karlsruhe?

The fastest takes 8h35; the slowest 10h50, for 450 km as the crow flies.

When do the buses leave?

The earliest leaves at 06:40 and the latest at 22:00, local time in Prague. Not every bus runs every day: pick a date above.

Is there a night bus from Prague to Karlsruhe?

Yes: 1 overnight departure in the timetable, for example 22:00 arriving 06:35 the next morning.

Prague ▸ Karlsruhe

Direct buses · no change

Quick answers

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