Avignon to Karlsruhe bus: 2.1 a day, fastest 10h50

2.1 a dayfastest 10h50☾ 3 overnight busesBlaBlaCar Bus, FlixBus🇫🇷 France → 🇩🇪 Germany

Direct buses · no change

AvignonLyonChalon-sur-SaôneBelfortMulhouseColmarKarlsruhe· 626 km as the crow flies

00:15 → 11:05
FlixBus N1135 ☾ Overnight
Avignon (Le Pontet) → Karlsruhe central train station · via Lyon, Mulhouse, Freiburg, Strasbourg
10h504 stops
Runs: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sun 25 Oct: 00:15 → 10:05)Book on FlixBus ↗
00:35 → 11:35
BlaBlaCar Bus ☾ Overnight
Avignon - Le Pontet - Le Lac Stop → Karlsruhe - Central Station South Side · via Lyon, Mulhouse, Colmar, Strasbourg
11h004 stops
Runs: Tue, Sat, Sun (some weeks)The night the clocks change (Sun 25 Oct: 00:35 → 10:35)Book on BlaBlaCar Bus ↗
19:00 → 06:20⁺¹
FlixBus N1315 ☾ Overnight
Avignon (Le Pontet) → Karlsruhe central train station · via Lyon, Chalon-sur-Saône, Belfort, Mulhouse…
11h206 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 19:00 → 05:20+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026) and BlaBlaCar Bus (file of 18 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. Contains BlaBlaCar Bus timetable data (transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

☾ Overnight: leave 00:15, arrive 11:05

The train is 5h27 quicker door to door, but the night bus spends your night on the road instead of a day.

Bus · fastest direct11h38

To Avignon (Le Pontet)19 min
At the stop before departure15 min
FlixBus N113510h50
From Karlsruhe central train station14 min

Train · fastest direct6h11

Before departure10 min
671A6h00
From Karlsruhe Hbf1 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

1 a daydirect trains, fastest 6h00

Société Nationale des Chemins de fer Français. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Flying instead?

Nothing flies Avignon to Karlsruhe nonstop in picktheflight's airline data.

Check flights on picktheflight ↗

Quick answers

Is there a direct bus from Avignon to Karlsruhe?

Yes. 2.1 a day on average, with BlaBlaCar Bus and FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Avignon to Karlsruhe?

The fastest takes 10h50; the slowest 11h20, for 626 km as the crow flies.

When do the buses leave?

The earliest leaves at 00:15 and the latest at 19:00, local time in Avignon. Not every bus runs every day: pick a date above.

Is there a night bus from Avignon to Karlsruhe?

Yes: 3 overnight departures in the timetable, for example 00:15 arriving 11:05.

Avignon ▸ Karlsruhe

Direct buses · no change

Quick answers

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