Prague ▸ Lyon
Lyon ▸ Prague ⇄3.3 a dayfastest 15h15☾ 3 overnight busesFlixBus🇨🇿 Czechia → 🇫🇷 France
Direct buses · no change
PraguePlzeňNurembergHeilbronnStuttgartKarlsruheLyon· 860 km as the crow flies
- 06:40 → 23:15FlixBus N1316Prague (Central Bus Station Florenc) → Lyon (Gerland Bus Station) · via Beroun, Nuremberg, Heilbronn, Stuttgart…16h3512 stopsRuns: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sun 25 Oct: 05:40 → 22:15)Book on FlixBus ↗
- 15:10 → 08:15+1FlixBus N1315 ☾ OvernightPrague (Central Bus Station Florenc) → Lyon (Gerland Bus Station) · via Plzeň, Nuremberg, Heilbronn, Stuttgart…17h0514 stops
- 16:15 → 09:05+1FlixBus N106 ☾ OvernightPrague (Main Railway Station) → Lyon (Gerland Bus Station) · via Munich, Memmingen, Lindau, Bregenz…16h509 stopsRuns: Mon, Thu, Fri, Sat, Sun (some weeks)The night the clocks change (Sat 24 Oct: 16:15 → 08:05+1)Book on FlixBus ↗
- 21:25 → 12:40+1FlixBus N1759 ☾ OvernightPrague (Central Bus Station Florenc) → Lyon (Gerland Bus Station) · via Nuremberg, Freiburg, Mulhouse, Belfort…15h158 stops
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Prague to Lyon?
Yes. 3.3 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Prague to Lyon?
The fastest takes 15h15; the slowest 17h05, for 860 km as the crow flies.
When do the buses leave?
The earliest leaves at 06:40 and the latest at 21:25, local time in Prague. Not every bus runs every day: pick a date above.
Is there a night bus from Prague to Lyon?
Yes: 3 overnight departures in the timetable, for example 15:10 arriving 08:15 the next morning.